C.N.R., IASI BioMatLab
UCSC, Largo A. Gemelli 8
00168 Rome, Italy.
Tel. +39-06-30155389
Fax +39-06-3057845
In the year 2001 the Institute for Systems Analysis and Informatics (IASI) and the Center for the Study of the Pathophysiology of Shock (CFS), both organs of the Italian National Research Council (CNR), merged and the current IASI "A. Ruberti" was born. Pivotal in this merger was the long-standing collaboration of former IASI and CFS researchers on biomathematics research themes, specifically on the modelling of endocrine and metabolic systems. BioMatLab, a laboratory specifically geared to research in biomathematics born in 1997 within CFS, is now part of IASI "A. Ruberti": it is located within the Catholic University School of Medicine, at the Policlinico Gemelli Hospital in Rome, next to the Institute for Clinical Surgery directed by Prof. Marco Castagneto (also Director of CFS).
The Laboratory is mainly dedicated to applied mathematical modelling on biomedical themes and to research in estimation techniques for nonlinear dynamical models and stochastic differential equations models. We have participated in several projects together with medical researchers (on the glucose-insulin system, on the metabolism of dicarboxylic and medium-chain fatty acids, on the distribution of resistances and compliances in the pulmonary vascular tree, on the production and elimination of Nitric Oxide in the airways, on MicroArrays, on noninvasive assisted ventilation, on antimicrobial efficacy, on indirect calorimetry, on the characterization of animal embrio development under sublethal toxicants), where we have provided the necessary mathematical and statistical expertise for experimental design, for data analysis and modelling, and for the conduction of multi-center clinical trials. We are very much interested, both from a practical and from a theoretical point of view, in statistical parameter estimation. We work on population parameter estimation, both frequentist and Bayesian, on parameter estimation for Stochastic Differential Equations models and on the relevance of measures of model nonlinearity for the computation of parameter confidence regions.
Research Interests
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Active collaborations
The laboratory has strong ties with a few external research groups, both national and international:
With Prof. Geltrude Mingrone from the Dept. of Clinical Medicine, Catholic University School of Medicine in Rome, we have been collaborating for many years on glucose/insulin regulation and on dicarbolylic and medium-chain fatty acid metabolism.
With the group of Prof. Franz Kappel (Dept. Of Mathematics, Karl-Franzen Universitaet Graz) and Dr. Kotanko (Barmherzigen Brueder Krankenhaus Graz) we study dynamical models of glucose control in Type 1 diabetes patients over long stretches of time (years), as well as collaborating in the organization of European Summer Schools in BioMathematics.
Together with Prof. Susanne Ditlevsen and Prof. Peter Dalgaard and colleagues from the Dept. of BioStatistics, University of Copenhagen, we are trying to use Stochastic Differential Equations models to represent intrinsic system noise in metabolic control systems.
With Prof. Yongwimon Lenbury (Dept. Of Mathematics, Mahidol University Bangkok) and her colleagues, a well as with Prof. D. Giang (Viet-Nam Academy of Sciences, Hanoi) we collaborate on the study of qualitative properties of delay differential models of the glucose-insulin system, as well as on other differential models of physiological processes.
With Prof. George Cremona of the Dept. of Pulmonary Medicine, San Raffaele University Hospital in Milan, we studied pulmonary vascular properties and airway exchange of NO, and are continuing investigations on inhaled drug longitudinal distribution.
With the group of the late Prof. Ovide Arino and coworkers (Université de Pau et des Pays de l'Adour, Pau; and Institut de Rechérche pour le Devéloppement, Bondy, Paris, Faculte` des Sciences Semlalia, Marrakech) we have collaborated on the demonstration of qualitative properties of ODE and delay-differential models of the glucose/insulin system, as wells as on the organization of the Biomathematics Summer Schools.
With Prof. Edoardo Beretta and Prof. Fortunata Solimano, from the Dept. of Biomathematics of the University of Urbino, we did some work on glucose-insulin models, on the forecasting of landslide occurrences, on ecologic niche models, as well as participating in their didactic activity at the Istituto di Biomatematica of Urbino University.
With the group of Prof. Maurizio Severini (C.N.R. Istituto di Scienze dell'Atmosfera e del Clima, Roma) and Dr. Vincent Hull (Laboratorio Nazionale di Idrobiologia, Roma) we studied the alterations of embrio development under nonlethal toxicant exposure, such as U.V. radiation.
With the group of Dr. Andrea Morelli (Institute of Anesthesiology, University Rome 1 "La Sapienza") we participated in modeling physiological system failure and recovery under sepsis, particularly renal function.
With the group of Prof. Rafael Bravo de la Parra (Dept. Mathematics, Alcala) and Prof. Eva Sanchez (Escuela Tecnica Superior Ingenieros Industriales, Madrid), we have organized several European Biomathematics Summer Schools, now continuing under the auspices of the European Society for Mathematical and Theoretical Biology.
With Prof. Paolo Fergola, from the Dept. of Mathematics, University of Naples Federico II, we have collaborated on deterministic and stochastic models of polluted chemostats.
With Prof. Misra, from the Dept. of Mathematics, Kharagpur Politechnic, we have published review work on general biomathematics and parameter estimation.
Historical collaborations
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Biomathematics Summer School |
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Second Biomathematics Summer School |
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1st ESMTB Euro Summer School |
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2nd ESMTB Euro Summer School |
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3rd ESMTB Euro Summer School |
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4th ESMTB Euro Summer School |
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5th ESMTB Euro Summer School |
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6th ESMTB Euro Summer School |
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7th ESMTB Euro Summer School |
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8th ESMTB Euro Summer School and Workshop |
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9th ESMTB Euro Summer School |
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10th ESMTB Euro Summer School |
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Andrea De Gaetano M.D., Ph.D. Mathematics e-mail: andrea (dot) degaetano (at) biomatematica (dot) it Personal page |
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Simona Panunzi Ph.D. Statistics e-mail: simona (dot) panunzi (at) biomatematica (dot) it Personal page |
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Pasquale Palumbo Ph.D. Engineering e-mail: palumbo (at) iasi (dot) rm (dot) cnr (dot) it |
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Claudio Gaz Dr. Engineering e-mail: claudio (dot) gaz (at) biomatematica (dot) it |
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Arnaldo Risi Ph.D. Operations Research e-mail: arnaldo (dot) risi (at) iasi (dot) cnr (dot) it web-site: http://www.iasi.cnr.it/~risi/ |
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Alice Matone Dr. Molecular Biology and Genomic Biotechnology e-mail: alice (dot) matone (at) libero (dot) it |
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Puntip Toghaw Assistant Professor, Mathematics e-mail: tiptoghaw (at) yahoo (dot) com |
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Sutharot Lueabunchong PhD candidate, Mathematical Statistics e-mail: Sutharot_luea (at) hotmail (dot) com |
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Kiattiyot Juagwon PhD candidate, Mathematics e-mail: daoke99 (at) hotmail (dot) com |
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Lorenzo Marchesi EU programs e-mail: lorenzo (dot) marchesi (at) biomatematica (dot) it |
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Valentina Zecchiaroli Administrative Assistant e-mail: valentina (dot) zecchiaroli (at) biomatematica (dot) it |
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Mariella Galasso Administrative Assistant e-mail: mariella (dot) galasso (at) biomatematica (dot) it |
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Simeone Marino, Univ. Michigan, Ann Arbor Dr. Statistics |
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Amitava Mukhopadhyay Ph.D. Mathematics, Kalailal Vidyamandir, Chandannagar |
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Luigi Granato Dr. Engineering |
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Deborah Giordano Dr. Statistics |
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Fabrizio Clarelli Dr. Physics |
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Claudio Cifarelli Dr. Statistics |
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Giuliana Cortese Dr. Statistics |
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Valeria Poli Dr. Statistics |
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Alessia Mammone Dr. Statistics |
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Andrea Giorgi M.D. |
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Umberto Picchini Ph.D. Statistics |
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Giordana Freddi Dr. Engineering |
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Alessandra Testa Dr. Biology |
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Nuengruithai Songtimool Dr. Statistics |