BioMatLab - Andrea De Gaetano

Andrea De Gaetano M.D., Ph.D. (Math), J.D.

Mail Address:
BioMatLab CNR-IASI, Fisiopatologia dello Shock
Università Cattolica del Sacro Cuore
Largo A. Gemelli 8 - 00168 Roma (Italy)
Tel.: +39-06-30155389
Fax: +39-06-3057845
e-mail: andrea.degaetano@biomatematica.it

Andrea De Gaetano, born march 5th 1959 in Milan, Italy. Nationality: Italian. Bilingual Italian-English, good French, good German. Programs fluently in C++ and MATLAB.

Academic degrees

- M.D., Doctor of Medicine (Catholic University School of Medicine, Roma, Italy, 1984; summa cum laude);
- Specialty in Emergency Surgery (State University at Milan, Milano, Italy, 1989; 70/70 score);
- M.Sc., Master in Applied Mathematics (UMBC, University of Maryland at Baltimore County, Baltimore, USA, 1991; core curricula in Analysis and Algebra);
- Ph.D. in Applied Mathematics (Universite’ de Pau et des Pays de l’Adour, Pau, France, 1995; Dynamical Systems, félicitations, summa cum laude).
- J.D. Juris Doctor (Urbino University School of Law, Laurea Magistrale in Giurisprudenza, Urbino, Italy, 2009; Civil Procedure, 106/110 score).

Research Interests

- Qualitative study and parameter estimation for differential models of biological processes.
- Differential-geometric techniques for establishing parameter confidence regions.
- Quasi-likelihood methods for population parameter estimation.
- Application of Stochastic Differential Equations to physiological modelling.

Positions

- 2006-present: Visiting Professor of Mathematical Statistics, Dept. of Mathematics, Mahidol University Bangkok, Thailand
- 2003-2005: Visiting Professor of Mathematical Statistics, Dept. of Biostatistics, University of Copenhagen, Denmark
- 2001-2004: Professor of Mathematical Statistics, Faculty of Sciences, University of Urbino.
- 2001-present: Director of Research, CNR IASI Fisiopatologia Shock, Rome.
- 1997-present: Head, Biomathematics Lab, CNR IASI Fisiopatologia Shock, Rome.
- 1995-2007: Professor of Statistics, School of Internal Medicine, Catholic University, Rome.
- 1990-2001: Researcher, National Research Council (CNR) IASI Fisiopatologia Shock, Rome.
- 1988-1989: Resident in General Surgery, Union Memorial Hospital, Baltimore, MD.
- 1987-1988: Deputy Director, Mathematical Research, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD.
- 1986-1987: Research Fellow, Mathematical Research, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD.

Grants

- Italian Work Ministry 1990-1992, responsible statistician: "Determinants of the mortality from trauma" (multi-center, principal investigator Daniele Gui).
- Telethon 1998-1999, responsible modeller-statistician: "Botulinum toxin in hypertrophic pyloric stenosis (single-center, principal investigator Daniele Gui)
- CNR, National Research Council, 1998-2000, within the strategic project "Mathematical Methods and Models in the Biological Sciences" (principal investigator Mimmo Iannelli): coordinator of subproject "Delay Differential Equations for Endocrine Modelling"
- European Commission 1999, principal investigator : "Summer School on Mathematics in Cell Physiology and Proliferation, Termoli 1999".
- European Commission 2000, principal investigator : "BIOMATHMFRANCA2000 Biomathematics Euro Summer School on 'Spatial Structures in Biology and Ecology: Models and Methods', Martina Franca September 2000".
- Italian Health Ministry 2000-2002, responsible modeller-statistician: "Homocysteine kinetics and health risk" (multi-center, principal investigator Letizia Petroni).
- MURST (Italian Ministry for University and Scientific Research) 2000-2001 "Botulinum toxin action pathways in the central nervous system" (principal investigator Giovanni Zaninotto): responsible statistician for the subunit "Human studies" (Daniele Gui).
- MURST (Italian Ministry for University and Scientific Research) 1999-2001, responsible modeller-statistician: "Integrated strategies for the reduction of mortality in ICU-admitted multiple trauma patients" (multi-center, principal investigator Marco Castagneto).
- European Commission 2001, principal investigator : "URBIOMATH2002: Biomathematics Euro Summer School on 'Dynamical Systems in Physiology and Medicine', Urbino, July 2002".
- European Commission 2002, head of Operating Unit CNR IASI for project "IST-2001-37403 HEARTS Health Early Alarm Recognition and Telemonitoring System", FP5 Information Society Technologies (IST).
- European Commission 2006, "BioMathTech 07-10: Mathematical Modeling of Physiologial Systems with Biomedical Applications:, Fp6 Marie Curie Series of Events, Coordinator of the 2009 School on Parameter Estimation for Dynamical Systems".
- European Commission 2008, Scientific Coordinator and Head of CNR IASI Operating Unit for project "FP7-SEC-2007-1-217855 SICMA Simulation of Crisis Management Activities", FP7 Security: Intelligent Decision Support.

Affiliations

- Member, ESMTB European Society for Mathematical and Theoretical Biology
- Member, EASD European Association for the Study of Diabetes

Editorial work

- Past Editor, European Communications in Mathematical and Theoretical Biology
- Associate Editor (Statistics), Intensive Care Medicine

Academic duties (graduate program advisor)

- Faculty of Computer Science, State University at Milan
- Faculty of Statistics, State University at Rome 1
- Faculty of Medicine, Catholic University, Rome
- Faculty of Engineering, State University at Rome 1
- PhD Program, Operations Research, State University at Rome 1
- PhD Program, Methodological Statistics, State University at Rome 1
- PhD Program, Copenhagen University, Denmark
- PhD Program, Mahidol University, Bangkok Thailand

List Of Publications

Papers on international peer-review journals:

1) Pizzi, R.; De Gaetano, A.; Guadalupi, P.; Chiara, O.; Columbano, C.; Sicurello, F. Prediction of MSOF Evolution by Means of Nine Vital Systems Trajectories. In Lecture Notes in Medical Informatics (36); Springer Verlag: New York, 1988.
2) Pizzi, R.; De Gaetano, A.; Guadalupi, P.; Chiara, O. On- and Off-Line Surveillance of the Critically Ill Patient. J. Clin. Comput. 1988, 17, 67-72.
3) Coleman, W. P.; Sanford, D.; De Gaetano, A. Syntax and Semantics of Languages for Medical Information Processing. 15th Northeast Bioengineering Conference (IEEE),Boston 1989, 189-190.
4) Laghi, F.; Siegel, J. H.; Rivkind, A. I.; Chiarla, C.; De Gaetano, A.; Blevins, S.; Stoklosa, J. C.; Borg, U. R.; Belzberg, H. Respiratory Index/Pulmonary Shunt Relationship: Quantification of Severity and Prognosis in the Post-Traumatic Adult Respiratory Distress Syndrome. Crit Care Med. 1989, 17, 1121-1128.
5) Coleman, W. P.; Sanford, D. P.; De Gaetano, A.; Geisler, F. H. Functional Models of Neurobiological Processes. J. Math. Comput. Modelling 1990, 14, 317-321.
6) Coleman, W. P.; Siegel, J. H.; Giovannini, I.; De Gaetano, A.; Goodarzi, S.; Tacchino, R. M.; Sganga, G. Probability and the Patient State Space. Int. J. Clin. Monit. Comput. 1990, 7, 201-215.
7) Coleman, W. P.; Sanford, D. P.; De Gaetano, A.; Geisler, F. H. Logical Structure of Neurobiological Information Processing. In Computing in the 90's - Lecture Notes in Computer Science (507); Sherwani, N., Ed.; Springer Verlag: New York, 1991.
8) Rivkind, A. I.; Siegel, J. H.; Littleton, M.; De Gaetano, A.; Mamantov, T.; Laghi, F.; Stoklosa, J. C. Neutrophil Oxidative Burst Activation and the Pattern of Respiratory Physiologic Abnormalities in the Fulminant Post-Traumatic Adult Respiratory Distress Syndrome. Circ. Shock 1991, 33, 48-62.
9) Coleman, W. P.; Sanford, D. P.; De Gaetano, A. Sintassi e Semantica Del Linguaggio Descrittivo Dell'Informazione Medica (Syntax and Semantics of the Language Describing Medical Information). Medicina e Informatica 1992, 3, 169-171.
10) Greco, A. V.; Mingrone, G.; Raguso, C.; Tataranni, A.; Finotti, E.; Tacchino, R. M.; Capristo, E.; De Gaetano, A.; Castagneto, M. Metabolic Effects and Disposition of Sebacate, an Alternate Dicarboxylic Fuel Substrate. Ann. Nutr. Metab 1992, 36, 1-11.
11) Tataranni, P. A.; Mingrone, G.; De Gaetano, A.; Raguso, C.; Greco, A. V. Tracer Study of Metabolism and Tissue Distribution of Sebacic Acid in Rats. Ann. Nutr. Metab 1992, 36, 296-303.
12) Coleman, W. P.; Siegel, J. H.; Giovannini, I.; Sanford, D. P.; De Gaetano, A. Computational Logic: a Method for Formal Analysis of the ICU Knowledge Base. Int. J. Clin. Monit. Comput. 1993, 10, 67-79.
13) De Gaetano, A.; Coleman, W. P.; Pizzi, R.; Tomasella, E.; Castagneto, M.; Greco, A. V. Hydra: a C-Language Environment for Real-Time DOS Multitasking at the Bedside. Int. J. Clin. Monit. Comput. 1993, 10, 147-154.
14) Greco, A. V.; Mingrone, G.; Tataranni, P. A.; Raguso, C.; De Gaetano, A.; Tacchino, R. M.; Lavielle, R.; Ghirlanda, G. Turnover and Oxidation Rates of Plasma-Free Fatty Acids in Obese Patients Treated With Dexfenfluramine. Ann. Nutr. Metab 1993, 37, 237-244.
15) Mingrone, G.; Greco, A. V.; Castagneto, M.; De Gaetano, A.; Tataranni, P. A.; Raguso, C. Kinetics and Thermogenesis of Medium-Chain Monocarboxylic and Dicarboxylic Acids in Man: Sebacate and Medium-Chain Triglycerides. JPEN J. Parenter. Enteral Nutr. 1993, 17, 257-264.
16) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Raguso, C.; Tataranni, P. A.; Castagneto, M. A Rapid GLC Method for the Direct Analysis of Plasma Medium Chain Fatty Acids. Clin. Chim. Acta 1993, 214, 21-30.
17) Castagneto, M.; De Gaetano, A.; Mingrone, G.; Tacchino, R. M.; Nanni, G.; Capristo, E.; Benedetti, G.; Tataranni, P. A.; Greco, A. V. Normalization of Insulin Sensitivity in the Obese Patient After Stable Weight Reduction With Bilio-Pancreatic Diversion. Obesity Surgery 1994, 4, 161-168.
18) De Gaetano, A.; Castagneto, M.; Mingrone, G.; Coleman, W. P.; Sganga, G.; Tataranni, P. A.; Gangeri, G.; Greco, A. V. PC-Based Differential Model Fitting As a Support for Clinical Research. Int. J. Clin. Monit. Comput. 1994, 11, 35-41.
19) De Gaetano, A.; Castagneto, M.; Mingrone, G.; Gangeri, G.; Sganga, G.; Tataranni, P. A.; Raguso, C.; Greco, A. V. Kinetics of Medium-Chain Triglycerides and Free Fatty Acids in Healthy Volunteers and Surgically Stressed Patients. JPEN J. Parenter. Enteral Nutr. 1994, 18, 134-140.
20) Mingrone, G.; Greco, A. V.; De Gaetano, A.; Tataranni, A.; Raguso, C.; Castagneto, M. Pharmacokinetic Profile of Dodecanedioic Acid, a Proposed Alternative Fuel Substrate. JPEN J. Parenter. Enteral Nutr. 1994, 18, 225-230.
21) Raguso, C. A.; Mingrone, G.; Greco, A. V.; Tataranni, P. A.; De Gaetano, A.; Castagneto, M. Dicarboxylic Acids and Glucose Utilization in Humans: Effect of Sebacate. JPEN J. Parenter. Enteral Nutr. 1994, 18, 9-13.
22) Scambia, G.; Benedetti, P. P.; Foti, E.; Amoroso, M.; Salerno, G.; Ferrandina, G.; Battaglia, F.; Greggi, S.; De Gaetano, A.; Puglia, G. Squamous Cell Carcinoma Antigen: Prognostic Significance and Role in the Monitoring of Neoadjuvant Chemotherapy Response in Cervical Cancer. J. Clin. Oncol. 1994, 12, 2309-2316.
23) Tataranni, P. A.; Mingrone, G.; Greco, A. V.; Caradonna, P.; Capristo, E.; Raguso, C. A.; De Gaetano, A.; Tacchino, R. M.; Castagneto, M. Glucose-Induced Thermogenesis in Postobese Women Who Have Undergone Biliopancreatic Diversion. Am. J. Clin. Nutr. 1994, 60, 320-326.
24) Greco, A. V.; Tataranni, P. A.; Mingrone, G.; De Gaetano, A.; Manto, A.; Cotroneo, P.; Ghirlanda, G. Daily Energy Metabolism in Patients With Type 1 Diabetes Mellitus. J. Am. Coll. Nutr. 1995, 14, 286-291.
25) Greco, A. V.; Mingrone, G.; Capristo, E.; De Gaetano, A.; Ghirlanda, G.; Castagneto, M. Effects of Dexfenfluramine on Free Fatty Acid Turnover and Oxidation in Obese Patients With Type 2 Diabetes Mellitus. Metabolism 1995, 44, 57-61.
26) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Castagneto, M.; Gasbarrini, G. Medium-Chain Triglycerides for Parenteral Nutrition: Kinetic Profile in Humans. Nutrition 1995, 11, 418-422.
27) De Gaetano, A.; Mingrone, G.; Castagneto, M. NONMEM Improves Group Parameter Estimation for the Minimal Model of Glucose Kinetics. Am. J. Physiol 1996, 271, E932-E937.
28) Gui, D.; Spada, P. L.; De Gaetano, A.; Pacelli, F. Hypocholesterolemia and Risk of Death in the Critically Ill Surgical Patient. Intensive Care Med. 1996, 22, 790-794.
29) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Benedetti, G.; Capristo, E.; Castagneto, M.; Gasbarrini, G. Plasma Clearance and Oxidation of Dodecanedioic Acid in Humans. JPEN J. Parenter. Enteral Nutr. 1996, 20, 38-42.
30) Tataranni, P. A.; Mingrone, G.; Raguso, C. A.; De Gaetano, A.; Tacchino, R. M.; Castagneto, M.; Greco, A. V. Twenty-Four-Hour Energy and Nutrient Balance in Weight Stable Postobese Patients After Biliopancreatic Diversion. Nutrition 1996, 12, 239-244.
31) Bertuzzi, A.; Mingrone, G.; De Gaetano, A.; Gandolfi, A.; Greco, A. V.; Salinari, S. Kinetics of Dodecanedioic Acid and Effect of Its Administration on Glucose Kinetics in Rats. Br. J. Nutr. 1997, 78, 143-153.
32) Greco, A. V.; Mingrone, G.; De Gaetano, A.; Amigo, L.; Puglielli, L.; Castagneto, M.; Nervi, F. Uptake of Dodecanedioic Acid by Isolated Rat Liver. Clin. Chim. Acta 1997, 258, 209-218.
33) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Dodecanedioic Acid Infusion Induces a Sparing Effect on Whole-Body Glucose Uptake, Mainly in Non-Insulin-Dependent Diabetes Mellitus. Br. J. Nutr. 1997, 78, 723-735.
34) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Reversibility of Insulin Resistance in Obese Diabetic Patients: Role of Plasma Lipids. Diabetologia 1997, 40, 599-605.
35) Castagneto, M.; De Gaetano, A.; Mingrone, G.; Capristo, E.; Benedetti, G.; Tacchino, R. M.; Greco, A. V.; Gasbarrini, G. A Surgical Option for Familial Chylomicronemia Associated With Insulin- Resistant Diabetes Mellitus. Obes. Surg. 1998, 8, 191-198.
36) Greco, A. V.; Mingrone, G.; Capristo, E.; Benedetti, G.; De Gaetano, A.; Gasbarrini, G. The Metabolic Effect of Dodecanedioic Acid Infusion in Non-Insulin- Dependent Diabetic Patients. Nutrition 1998, 14, 351-357.
37) Mingrone, G.; Benedetti, G.; Capristo, E.; De Gaetano, A.; Greco, A. V.; Tataranni, P. A.; Gasbarrini, G. Twenty-Four-Hour Energy Balance in Crohn Disease Patients: Metabolic Implications of Steroid Treatment. Am. J. Clin. Nutr. 1998, 67, 118-123.
38) Andreotti, F.; Sciahbasi, A.; De Gaetano, A.; Benedetti, G.; Mingrone, G.; Greco, A. V.; Maseri, A. Comparison of Insulin Response to Intravenous Glucose in Healed Myocardial Infarction, in "Cooled-Off" Unstable and Stable Angina Pectoris, and in Healthy Subjects. Am. J. Cardiol. 1999, 84, 870-875.
39) Capristo, E.; Mingrone, G.; De Gaetano, A.; Addolorato, G.; Greco, A. V.; Gasbarrini, G. A New HPLC Method for the Direct Analysis of Triglycerides of Dicarboxylic Acids in Biological Samples. Clin. Chim. Acta 1999, 289, 11-21.
40) Capristo, E.; De Gaetano, A.; Mingrone, G.; Addolorato, G.; Greco, A. V.; Castagneto, M.; Gasbarrini, G. Multivariate Identification of Metabolic Features in Inflammatory Bowel Disease. Metabolism 1999, 48, 952-956.
41) De Gaetano, A.; Arino, O. Probabilistic Determination of Stability for a Delay-Differential Model of the Glucose-Insulin Dynamical System. J. Biol. Systems 1999, 7(2), 131-144.
42) De Gaetano, A.; Mingrone, G.; Castagneto, M.; Calvani, M. Carnitine Increases Glucose Disposal in Humans. J. Am. Coll. Nutr. 1999, 18(4), 289-295.
43) De Gaetano, A.; Mingrone, G.; Castagneto, M.; Benedetti, G.; Greco, A. V.; Gasbarrini, G. Kinetics of Dodecanedioic Acid Triglyceride in Rats. Am. J. Physiol 1999, 276, E497-E502.
44) Mingrone, G.; De Gaetano, A.; Pugeat, M.; Capristo, E.; Greco, A. V.; Gasbarrini, G. The Steroid Resistance of Crohn's Disease. J. Investig. Med. 1999, 47, 319-325.
45) Mingrone, G.; Greco, A. V.; Capristo, E.; Benedetti, G.; Giancaterini, A.; De Gaetano, A.; Gasbarrini, G. L-Carnitine Improves Glucose Disposal in Type 2 Diabetic Patients. J. Am. Coll. Nutr. 1999, 18, 77-82.
46) Mingrone, G.; Capristo, E.; Greco, A. V.; Benedetti, G.; De Gaetano, A.; Tataranni, P. A.; Gasbarrini, G. Elevated Diet-Induced Thermogenesis and Lipid Oxidation Rate in Crohn Disease. Am. J. Clin. Nutr. 1999, 69, 325-330.
47) Mingrone, G.; De Gaetano, A.; Greco, A. V.; Capristo, E.; Benedetti, G.; Castagneto, M.; Gasbarrini, G. Comparison Between Dodecanedioic Acid and Long-Chain Triglycerides As an Energy Source in Liquid Formula Diets. JPEN J. Parenter. Enteral Nutr. 1999, 23, 80-84.
48) Bartolozzi, F.; De Gaetano, A.; Di Lena, E.; Marino, S.; Nieddu, L.; Patrizi, G. Operational Research Techniques in Medical Treatment and Diagnosis. A Review. European Journal of Operations Research, EJOR 2000, 121/3, 435-466.
49) Capristo, E.; Addolorato, G.; Mingrone, G.; De Gaetano, A.; Greco, A. V.; Tataranni, P. A.; Gasbarrini, G. Changes in Body Composition, Substrate Oxidation, and Resting Metabolic Rate in Adult Celiac Disease Patients After a 1-y Gluten-Free Diet Treatment. Am. J. Clin. Nutr. 2000, 72, 76-81.
50) De Gaetano, A.; Arino, O. A Statistical Approach to the Determination of Stability for Dynamical Systems Modelling Physiological Processes. J. Math. Comput. Modelling 2000, 31, 41-51.
51) De Gaetano, A.; Arino, O. Mathematical Modelling of the Intravenous Glucose Tolerance Test. J. Math. Biol. 2000, 40, 136-168.
52) Giancaterini, A.; De Gaetano, A.; Mingrone, G.; Gniuli, D.; Liverani, E.; Capristo, E.; Greco, A. V. Acetyl-L-Carnitine Infusion Increases Glucose Disposal in Type 2 Diabetic Patients. Metabolism 2000, 49, 704-708.
53) Gui, D.; De Gaetano, A.; Spada, P. L.; Viggiano, A.; Cassetta, E.; Albanese, A. Botulinum Toxin Injected in the Gastric Wall Reduces Body Weight and Food Intake in Rats. Aliment. Pharmacol. Ther. 2000, 14, 829-834.
54) Manco, M.; Mingrone, G.; Greco, A. V.; Capristo, E.; Gniuli, D.; De Gaetano, A.; Gasbarrini, G. Insulin Resistance Directly Correlates With Increased Saturated Fatty Acids in Skeletal Muscle Triglycerides. Metabolism 2000, 49, 220-224.
55) Purro, A.; Appendini, L.; De Gaetano, A.; Gudjonsdottir, M.; Donner, C. F.; Rossi, A. Physiologic Determinants of Ventilator Dependence in Long-Term Mechanically Ventilated Patients [In Process Citation]. Am. J. Respir. Crit. Care Med. 2000, 161, 1115-1123.
56) Calvani, M.; Iddio, D.; De Gaetano, A.; Mariotti, P.; Mosconi, L.; Pomponi, M. G.; Tabolacci, E.; Torrioli, M. G.; Vernacotola, S.; Neri, G. [L Acetylcarnitine Treatment on Fragile X Patients Hyperactive Behaviour]. Rev. Neurol. 2001, 33 Suppl 1, S65-S70.
57) Giancaterini, A.; Mingrone, G.; De Gaetano, A.; Capristo, E.; Calvani, M.; Caso, V.; Greco, A. V.; Gasbarrini, G. Effects of Propyonil-l-Carnitine Topical Irrigation in Distal Ulcerative Colitis: a Preliminary Report. Am. J. Gastroenterol. 2001, 96, 2275-2276.
58) Mingrone, G.; Marino, S.; DeGaetano, A.; Capristo, E.; Heymsfield, S. B.; Gasbarrini, G.; Greco, A. V. Different Limit to the Body's Ability of Increasing Fat-Free Mass. Metabolism 2001, 50, 1004-1007.
59) Graziano, F.; Bisonni, R.; Catalano, V.; Silva, R.; Rovidati, S.; Mencarini, E.; Ferraro, B.; Canestrari, F.; Baldelli, A. M.; De Gaetano, A.; Giordani, P.; Testa, E.; Lai, V. Potential Role of Levocarnitine Supplementation for the Treatment of Chemotherapy-Induced Fatigue in Non-Anaemic Cancer Patients. Br. J. Cancer 2002, 86, 1854-1857.
60) Gui, D.; Runfola, M.; Rossi, S.; Panunzi, S.; De Gaetano, A. Academic Recruitment in Spain and Italy. Science 2002, 297, 770-771.
61) Marino, S.; De Gaetano, A.; Giancaterini, A.; Giordano, D.; Manco, M.; Greco, A. V.; Mingrone, G. Computing DIT From Energy Expenditure Measures in a Respiratory Chamber: a Direct Modeling Method. Comput. Biol. Med. 2002, 32, 297-309.
62) Gasbarrini, G.; Mingrone, G.; Giancaterini, A.; De Gaetano, A.; Scarfone, A.; Capristo, E.; Calvani, M.; Caso, V.; Greco, A. V. Effects of Propionyl-L-Carnitine Topical Irrigation in Distal Ulcerative Colitis: a Preliminary Report. Hepatogastroenterology 2003, 50, 1385-1389.
63) Muretto, P.; Graziano, F.; Staccioli, M. P.; Barbanti, I.; Bartolucci, A.; Paolini, G.; Giordano, D.; Testa, E.; De Gaetano, A. An Endogastric Capsule for Measuring Tumor Markers in Gastric Juice: an Evaluation of the Safety and Efficacy of a New Diagnostic Tool. Ann. Oncol. 2003, 14, 105-109.
64) Ruzzo, A.; Graziano, F.; Costagliola, A.; Arduini, F.; Testa, E.; Bearzi, I.; Cortese, G.; De Gaetano, A.; Andreoni, F.; Lai, V.; Magnani, M. The G/A Nucleotide Change at CDNA Position 2494 in the E-Cadherin Gene (CDH1): Analysis in Italian Patients. Tumour. Biol. 2003, 24, 147-150.
65) Severini, M.; Dattilo, A. M.; De Gaetano, A. Sublethal Effect of a Weak Intermittent Magnetic Field on the Development of Xenopus Laevis (Daudin) Tadpoles. Int. J. Biometeorol. 2003, 48, 91-97.
66) Ciampelli, M.; Leoni, F.; Cucinelli, F.; Mancuso, S.; Panunzi, S.; De Gaetano, A.; Lanzone, A. "Assessment of Insulin Sensitivity From Measurements in the Fasting State and During an Oral Glucose Tolerance Test in Polycystic Ovary Syndrome and Menopausal Patients". J. Clin. Endocrinol. Metab. 2005, 90, 1398-1406.
67) Morelli, A.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Coluzzi, F.; Vernaglione, E.; Pelaia, P.; Pietropaoli, P. Effects of Short-Term Fenoldopam Infusion on Gastric Mucosal Blood Flow in Septic Shock. Anesthesiology 2004, 101, 576-582.
68) Morelli, A.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Cortese, G.; Coluzzi, F.; Vernaglione, E.; Pelaia, P.; Pietropaoli, P. Effects of Terlipressin on Systemic and Regional Haemodynamics in Catecholamine-Treated Hyperkinetic Septic Shock. Intensive Care Med. 2004, 30, 597-604.
69) De Gaetano, A.; Cortese, G.; Pedersen, M.G., Panunzi, S., Picchini, U., Morelli, A. Modeling Serum Creatinine in Spetic ICU Patients. Cardiovasc. Engineering 2004, (4)2, 173-180. 70) Mukhopadhyay, A.; De Gaetano, A.; Arino, O. Modelling the Intra-Venous Glucose Tolerance Test: a Global Study for a Single-Distributed-Delay Model. Discr. Cont. Dyn. Syst. B 2004.
71) De Gaetano, A.; Panunzi, S. Nonlinear Estimation and Confidence Regions: a Biological Case Study. In Mathematical Models for Bioengineering and Probabilistic Systems; Misra, J. C., Ed.; Narosa: New Delhi, 2005.
72) Ditlevsen, S.; De Gaetano, A. Stochastic vs. deterministic uptake of dodecanedioic acid by isolated rat livers. Bull.Math.Biol. 67, 547-561. 2005.
73) Morelli, A.; Tritapepe, L.; Rocco, M.; Conti, G.; Orecchioni, A.; De Gaetano, A.; Picchini, U.; Pelaia, P.; Reale, C.; Pietropaoli, P. Terlipressin Versus Norepinephrine to Counteract Anesthesia-Induced Hypotension in Patients Treated With Renin-Angiotensin System Inhibitors: Effects on Systemic and Regional Hemodynamics. Anesthesiology 2005, 102, 12-19.
74) Morelli, A.; Ricci, Z.; Bellomo, R.; Ronco, C.; Rocco, M.; Conti, G.; De Gaetano, A.; Picchini, U.; Orecchioni, A.; Portieri, M.; Coluzzi, F.; Porzi, P.; Serio, P.; Bruno, A.; Pietropaoli, P. Prophylactic Fenoldopam for Renal Protection in Sepsis: a Randomized, Double-Blind, Placebo-Controlled Pilot Trial. Crit Care Med. 2005, 33, 2451-2456.
75) Panunzi, S.; De Gaetano, A.; Mingrone, G. Approximate Linear Confidence and Curvature of a Kinetic Model of Dodecanedioic Acid in Humans. Am. J. Physiol Endocrinol. Metab 2005.
76) Picchini, U.; De Gaetano, A.; Panunzi, S.; Ditlevsen, S.; Mingrone, G. A Mathematical Model of the Euglycemic Hyperinsulinemic Clamp. Theor. Biol. Med. Model. 2005, 2, 44.
77) A. Morelli, J.L. Teboul, S. M. Maggiore, A. Vieillard-Baron, M. Rocco, G. Conti, A. De Gaetano, U. Picchini, A. Orecchioni, I. Carbone, P. Pietropaoli, M. Westphal. "Effects Of Levosimendan On Right Ventricular Afterload In Patients With Acute Respiratory Distress Syndrome: A Pilot Study". Critical Care Medicine, 34(9):2287-2293, September 2006.
78) Rusciani L., Proietti I., Rusciani A., Paradisi A., Sbordoni G., Alfano C., Panunzi S., De Gaetano A., Lippa S. "Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression". J. Am. Acad. Dermatol. 2006 Feb;54(2):234-41.
79) Pavoni E., Pucci A., Vaccaro P., Monteriu G., Ceratti Ade P., Lugini A., Virdis RA., Cortesi E., De Gaetano A., Panunzi S., Felici F., Minenkova O. "A study of the humoral immune response of breast cancer patients to a panel of human tumor antigens identified by phage display". Cancer Detect Prev. 2006;30(3):248-56.
80) P. Palumbo, W.H. Ong-Clausen, S. Panunzi, A. De Gaetano, "Linear periodic models of subcutaneous insulin absorption: mathematical analysis". HERMIS Journal, Special Issue on Differential and Integral Equations in Physics, Epidemiology and Medicine: Applications and Numerics., Vol. 7, pp. 60-79, 2006.
81) W. H. O. Clausen, A. De Gaetano and A. Vølund. "Within-patient variation of the pharmacokinetics of subcutaneously injected biphasic insulin aspart as assessed by compartmental modelling". Diabetologia, 49(9):2030-2038, Sep. 2006.
82) U. Picchini, S. Ditlevsen and A. De Gaetano. "Modeling the euglycemic hyperinsulinemic clamp by stochastic differential equations". Journal of Mathematical Biology, 53(5), 771–796, Nov. 2006.
83) A. De Gaetano, S. Panunzi, B. Beck, B. Boulanger. Statistical Modeling in Pharmaceutical Research and Development, Chapter 3 of S. Eaking (Ed.) Computer Applications in Pharmaceutical Research and Development, John Wiley, 2006.
84) L. Rusciani, I. Proietti, A. Paradisi, A. Rusciani, G. Guerriero, A. Mammone, A. De Gaetano, S. Lippa. "Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up". Melanoma Research, Jun;17(3):177-83, 2007.
85) P. Palumbo, S. Panunzi, A. De Gaetano, ''Qualitative behavior of a family of delay-differential models of the glucose-insulin system'', Discrete and Continuous Dynamical Systems - Series B, Vol. 7, No. 2, pp. 399-424, 2007.
86) S. Panunzi, P. Palumbo and A. De Gaetano. "A discrete Single Delay Model for the Intra-Venous Glucose Tolerance Test", Theoretical Biology and Medical Modelling, 4:35 2007.
87) P. Palumbo, A. De Gaetano, “State-feedback control of the glucose-insulin system”, MATH EVERYWHERE. Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry. G. Aletti, M. Burger, A. Micheletti, D. Morale Editors, Springer, Heidelberg, pp.241-252, 2007.
88) Pasquale Palumbo, Umberto Picchini, Benoît Beck, Jan van Gelder, Nathalie Delbar and Andrea De Gaetano. A general approach to the apparent permeability index. Journal of Pharmacokinetics and Pharmacodynamics, 2008 35(2):235-48.
89) Umberto Picchini, Susanne Ditlevsen and Andrea De Gaetano. Maximum likelihood estimation of a time-inhomogeneous stochastic differential model of glucose dynamics. Mathematical Medicine and Biology, 2008.
90) Andrea De Gaetano, Thomas Hardy, Benoit Beck, Eyas Abu-Raddad, Pasquale Palumbo, Juliana Bue-Valleskey, Niels Porksen. Mathematical models of Diabetes progression. Am J Physiol Endocrinol Metab. 2008 295(6):E1462-79.
91) Umberto Picchini, Susanne Ditlevsen, Andrea De Gaetano, Peter Lansky. Parameters of the diffusion leaky integrate-and-fire neuronal model for a slowly fluctuating signal. Neural Comput. 2008 20(11):2696-714.
92) Morganti, A. G.; Deodato, F.; Zizzari, S.; Cilla, S.; Digesu', C.; Macchia, G.; Panunzi, S.; De Gaetano, A.; Piermattei, A.; Cellini, N.; Valentini, V. Complexity Index (COMIX) and Not Type of Treatment Predicts Undetected Errors in Radiotherapy Planning and Delivery. Radiother. Oncol. 2008, 89, 320-329.
93) Palumbo, P.; De Gaetano, A. An Islet Population Model of the Endocrine Pancreas. J Math. Biol. 2009.
94) Morganti, A. G.; Digesu, C.; Panunzi, S.; De Gaetano, A.; Macchia, G.; Deodato, F.; Cece, M. G.; Cirocco, M.; Di Castelnuovo, A.; Iacoviello, L.; Valentini, V.; Cellini, N.; de Gaetano, G. Radioprotective Effect of Moderate Wine Consumption in Patients With Breast Carcinoma. Int. J Radiat. Oncol. Biol. Phys. 2009, 74, 1501-1505.
95) Morganti, A. G.; Cilla, S.; Valentini, V.; Digesu', C.; Macchia, G.; Deodato, F.; Ferrandina, G.; Cece, M. G.; Cirocco, M.; Garganese, G.; Di Lullo, L.; Traficante, D.; Scarabeo, F.; Panunzi, S.; De Gaetano, A.; Sallustio, G.; Cellini, N.; Sofo, L.; Piermattei, A.; Scambia, G. Phase I-II Studies on Accelerated IMRT in Breast Carcinoma: Technical Comparison and Acute Toxicity in 332 Patients. Radiother. Oncol. 2009, 90, 86-92.
96) Picchini, U.; De Gaetano, A.; Ditlevsen, S. Stochastic Differential Mixed-Effects Models. Scandinavian Journal of Statistics. 2009, 1467/9469.